Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid or capsaicin receptor 1, that reduces pain and improves articular functions. Zucapsaicin has also been evaluated for the management of several conditions manifested by chronic nerve pain. These conditions include herpes simplex (HSV) infections, cluster headaches, migraine, and osteoarthritis of the knee. Zucapsaicin was approved by the Health Canada in 2010 as topical cream marketed under the brand name Zuacta but currently not FDA-approved. Its therapeutic use is listed as analgesics and osteoarthritis agents. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Civamide and Civanex. Its PubChem CID is 1548942.
Zucapsaicin
| CAS No | 25775-90-0 |
|---|---|
| Molecular Formula | C18H27NO3 |
| Molecular Weight | 305.40 g/mol |
| Synonyms | (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide |
Zoho Contact Form
"*" indicates required fields
Frequently Asked Questions
Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain.
The listed CAS number is 25775-90-0.
The listed molecular formula is C18H27NO3.
The listed molecular weight is 305.40 g/mol.
(Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide.
The source lists Civamide and Civanex.