Zasocitinib (NDI‑034858 / TAK‑279) is an investigational small molecule that selectively inhibits the TYK2 JH2 pseudokinase domain with sub-nanomolar potency. It has demonstrated the ability to curb cytokine-driven pathways—including IFN‑α–induced CXCL10 production and IL‑23–mediated STAT3 activation—across human, mouse, and rat immune cells, showing efficacy in animal models of arthritis and colitis bi. The directory classifies it as a under development API with a synthetic source/manufacturing origin. Other names for this substance include NDI-034858 and TAK-279. Its PubChem CID is 137441492.
Zasocitinib
| CAS No | 2272904-53-5 |
|---|---|
| Molecular Formula | C23H24N8O3 |
| Molecular Weight | 460.50 g/mol |
| Synonyms | N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo-1-pyridin-2-ylpyridin-3-yl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide |
Zoho Contact Form
"*" indicates required fields
Frequently Asked Questions
Zasocitinib (NDI‑034858 / TAK‑279) is an investigational small molecule that selectively inhibits the TYK2 JH2 pseudokinase domain with sub-nanomolar potency.
The listed CAS number is 2272904-53-5.
The listed molecular formula is C23H24N8O3.
The listed molecular weight is 460.50 g/mol.
N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo-1-pyridin-2-ylpyridin-3-yl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide.
The source lists NDI-034858 and TAK-279.