Zaprinast

Zaprinast is an experimental small-molecule drug first developed as a potential anti-allergic asthma treatment. It is best known as a key pharmacological precursor and lead compound in the development of PDE5 inhibitors like sildenafil (Viagra).It acts mainly as a selective inhibitor of cGMP-specific phosphodiesterases (particularly PDE5, PDE6, PDE9, and PDE11) and has since been identified as an agonist for the G protein-coupled receptor GPR35 and an inhibitor of the mitochondrial pyruvate carrier. It is grouped under the following drug class(es): PDE5 Inhibitors. The directory classifies it as a discontinued API with a synthetic source/manufacturing origin. Other names for this substance include Zaprinastum, Zaprinast and solid. Its PubChem CID is 135399235.