Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), that is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis. It is grouped under the following drug class(es): Alkylating agents. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Ixoten and Trofosfamidum. Its PubChem CID is 65702.
Trofosfamide
| CAS No | 22089-22-1 |
|---|---|
| Molecular Formula | C9H18Cl3N2O2P |
| Molecular Weight | 323.6 g/mol |
| Synonyms | N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine |
Zoho Contact Form
"*" indicates required fields
Frequently Asked Questions
Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), that is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM).
The listed CAS number is 22089-22-1.
The listed molecular formula is C9H18Cl3N2O2P.
The listed molecular weight is 323.6 g/mol.
N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine.
The source lists Ixoten and Trofosfamidum.