Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) – in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections. It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used to treat plasmodial infections. Its therapeutic use is listed as antibacterials and antibiotics. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Proloprim, Trimpex, Trimetoprim, Syraprim and Uretrim. Its PubChem CID is 5578.
Trimethoprim
| CAS No | 738-70-5 |
|---|---|
| Molecular Formula | C14H18N4O3 |
| Molecular Weight | 290.32 g/mol |
| Synonyms | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
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Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.
The listed CAS number is 738-70-5.
The listed molecular formula is C14H18N4O3.
The listed molecular weight is 290.32 g/mol.
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine.
The source lists Proloprim, Trimpex, Trimetoprim, Syraprim and Uretrim.