Tofacitinib

Tofacitinib is a pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis. Among its listed roles, it functions as a EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor and an antirheumatic drug. It is a pyrrolopyrimidine, a N-acylpiperidine, a nitrile and a tertiary amino compound. It is grouped under the following drug class(es): Immunosuppressants, JAK inhibitors, Kinase inhibitors and Tyrosine Kinase Inhibitors. Its therapeutic use is listed as anti-inflammatories, antirheumatic agents and dermatologicals. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Tasocitinib and tofacitinibum. Its PubChem CID is 9926791.