Tivozanib hydrochloride monohydrate

Tivozanib Hydrochloride is the hydrochloride salt of tivozanib, an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. It is grouped under the following drug class(es): Kinase inhibitors and VEGF inhibitors. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include fotivda, Tivozanib HCl hydrate and Cloridrato de Tivozanibe. Its PubChem CID is 11547978.