tert-Butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate

In the Bilastine synthesis, this compound serves as a Boc-protected benzimidazole-piperidine scaffold, which allows selective reactions and purification during multi-step synthesis. The 2-ethoxyethyl substitution on the benzimidazole nitrogen and the Boc protection on the piperidine nitrogen facilitate controlled chemical transformations. In subsequent steps, the Boc group is removed, and the resulting free amine is coupled with other intermediates, such as substituted phenylpropionic acid derivatives, to ultimately yield the Bilastine API. This intermediate is therefore crucial for constructing the core structure of Bilastine, although it is not an API itself. tert‑Butyl 4‑(1‑(2‑ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (CAS 1181267‑36‑6) is a key synthetic intermediate in the production of Bilastine, a non-sedating H1 antihistamine.