Tenofovir

Tenofovir (anhydrous) is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection. Among its listed roles, it functions as a HIV-1 reverse transcriptase inhibitor, an antiviral drug and a drug metabolite. It belongs to the class of phosphonic acids and a nucleoside analogue. It is the conjugate acid of tenofovir. It is grouped under the following drug class(es): DNA polymerase inhibitors, Nucleotides and Reverse Transcriptase Inhibitors. Its therapeutic use is listed as anti-infectives and antivirals. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Truvada, tenofovirum, (R)-PMPA and Tenofovir anhydrous. It is also listed for alternate use as: API Intermediate. Its PubChem CID is 464205.