Tafenoquine Succinate is the succinate salt form of tafenoquine, an orally bioavailable 8-aminoquinoline derivative, with antimalarial activity. Although the mechanism is not completely understood, upon administration, tafenoquine inhibits the parasitic enzyme heme polymerase in the blood stages of the parasites. This inhibits the conversion of the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Its therapeutic use is listed as antimalarials. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Arakoda and Krintafel. Its PubChem CID is 163761.
Tafenoquine succinate
| CAS No | 106635-81-8 |
|---|---|
| Molecular Formula | C28H34F3N3O7 |
| Molecular Weight | 581.6 g/mol |
| Synonyms | butanedioic acid;4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine |
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Frequently Asked Questions
Tafenoquine Succinate is the succinate salt form of tafenoquine, an orally bioavailable 8-aminoquinoline derivative, with antimalarial activity. Although the mechanism is not completely understood, upon administration, tafenoquine inhibits the parasitic enzyme heme polymerase in the blood stages of the parasites.
The listed CAS number is 106635-81-8.
The listed molecular formula is C28H34F3N3O7.
The listed molecular weight is 581.6 g/mol.
butanedioic acid;4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine.
The source lists Arakoda and Krintafel.