Tacrolimus Hydrate is used topically to treat inflammatory skin conditions like atopic dermatitis (eczema) and psoriasis by suppressing the immune system’s response in the skin. It is also used systemically, often in conjunction with other medications, to prevent the rejection of transplanted organs, including kidneys, liver, lungs, and hearts, by decreasing overall immune system activity. It is grouped under the following drug class(es): Calcineurin inhibitors and Immunosuppressants. Its therapeutic use is listed as anti-psoriatic agents, antirheumatic agents and dermatologicals. The directory classifies it as a commercial API with a fermentation-derived source/manufacturing origin. Other names for this substance include Tacrolimus hydrate, Tsukubaenolide hydrate and Prograf (TN). Its PubChem CID is 5282315.
Tacrolimus monohydrate
| CAS No | 109581-93-3 |
|---|---|
| Molecular Formula | C44H71NO13 |
| Molecular Weight | 822.0 g/mol |
| Synonyms | (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone;hydrate |
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Frequently Asked Questions
Tacrolimus Hydrate is used topically to treat inflammatory skin conditions like atopic dermatitis (eczema) and psoriasis by suppressing the immune system's response in the skin.
The listed CAS number is 109581-93-3.
The listed molecular formula is C44H71NO13.
The listed molecular weight is 822.0 g/mol.
(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone;hydrate.
The source lists Tacrolimus hydrate, Tsukubaenolide hydrate and Prograf (TN).