Saxagliptin hydrochloride dihydrate

Saxagliptin hydrochloride dihydrate is a crystalline form of saxagliptin, an oral hypoglycemic drug used for the treatment of type 2 diabetes mellitus. It belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. Saxagliptin works by increasing the levels of incretin hormones including GLP-1 and GIP, which in turn increase insulin release from pancreatic beta cells in a glucose-dependent manner and reduce glucagon secretion from pancreatic alpha cells. This leads to reduced fasting and postprandial blood glucose levels. It is grouped under the following drug class(es): DPP-4 inhibitors and Hypoglycemics. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include (1S, 3S and 5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride dihydrate. Its PubChem CID is 91617922.