Sacubitril sodium is a prodrug neprilysin inhibitor used mainly in combination with valsartan (as the combination drug sacubitril/valsartan, brand name Entresto) for treating chronic heart failure with reduced ejection fraction. It helps reduce the risk of cardiovascular death and hospitalization by increasing levels of beneficial natriuretic peptides (atrial natriuretic peptide [ANP], brain natriuretic peptide [BNP]) that promote vasodilation, natriuresis (excretion of sodium), and diuresis (urine production), thereby lowering blood volume and blood pressure. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include AHU-377 sodium salt and Ahu-377 sodium. Its PubChem CID is 23707568.
Sacubitril sodium
| CAS No | 149690-05-1 |
|---|---|
| Molecular Formula | C24H28NNaO5 |
| Molecular Weight | 433.5 g/mol |
| Synonyms | sodium;4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate |
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Frequently Asked Questions
Sacubitril sodium is a prodrug neprilysin inhibitor used mainly in combination with valsartan (as the combination drug sacubitril/valsartan, brand name Entresto) for treating chronic heart failure with reduced ejection fraction.
The listed CAS number is 149690-05-1.
The listed molecular formula is C24H28NNaO5.
The listed molecular weight is 433.5 g/mol.
sodium;4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate.
The source lists AHU-377 sodium salt and Ahu-377 sodium.