It provides the required (S)-enantiomer configuration of 5-methoxy-2-aminotetralin, which is then N-alkylated with 2-(2-thienyl)ethanol and demethylated to produce the final API, enhancing purity and stereoselectivity. (S)-2-Amino-5-methoxytetralin (S)-mandelate is a key chiral intermediate employed to synthesize Rotigotine, a dopamine agonist for Parkinson’s disease.
(S)-2-Amino-5-methoxytetralin (S)-mandelate
| API Name | Rotigotine |
|---|---|
| CAS No | 439133-67-2 |
| Molecular Formula | C19H23NO4 |
| Molecular Weight | 329.4 g/mol |
| Synonyms | (2S)-2-hydroxy-2-phenylacetic acid;(2S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine |
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Frequently Asked Questions
It provides the required (S)-enantiomer configuration of 5-methoxy-2-aminotetralin, which is then N-alkylated with 2-(2-thienyl)ethanol and demethylated to produce the final API, enhancing purity and stereoselectivity. (S)-2-Amino-5-methoxytetralin (S)-mandelate is a key chiral intermediate employed to synthesize Rotigotine, a dopamine agonist for Parkinson’s disease.
The CAS number of (S)-2-Amino-5-methoxytetralin (S)-mandelate is 439133-67-2.
The molecular formula of (S)-2-Amino-5-methoxytetralin (S)-mandelate is C19H23NO4.
The listed molecular weight of (S)-2-Amino-5-methoxytetralin (S)-mandelate is 329.4 g/mol.
(S)-2-Amino-5-methoxytetralin (S)-mandelate is listed as being used in connection with the following API: Rotigotine.
The listed synonym or IUPAC name for (S)-2-Amino-5-methoxytetralin (S)-mandelate is (2S)-2-hydroxy-2-phenylacetic acid;(2S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine.