(S)-2-((4-(Trifluoromethyl)phenoxy)methyl)oxirane

This specific epoxide structure provides the crucial stereochemistry needed for Seladelpar’s therapeutic activity as a selective PPAR-delta agonist, helping form its complex structure and influencing its interaction with biological targets, ultimately reducing liver inflammation and itching in PBC patients. (S)-2-((4-(Trifluoromethyl)phenoxy)methyl)oxirane serves as a key chiral building block or intermediate in the synthesis of Seladelpar (Livdelzi), the drug used for Primary Biliary Cholangitis (PBC).