(+-)-(R*,S*)-6-fluoro-3,4-dihydro-alpha-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol

It is often reacted with an epoxide, such as (±)-[1S*(S*)]-6-fluoro-3,4-dihydro-2H-1-benzopyran (formula III-B), to form the benzyl-protected Nebivolol dimer. (±)-(R*,S*)-6-fluoro-3,4-dihydro-alpha-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol is a key intermediate in the synthesis of Nebivolol, specifically used as a protected amine precursor to build the final molecule’s structure.

API Name Nebivolol
CAS No 99199-91-4
Molecular Formula C18H20FNO2
Molecular Weight 301.4 g/mol
Synonyms 2-(benzylamino)-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol