Risperidone

Risperidone is a second-generation antipsychotic (SGA) medication used to treat a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone). Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively. Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain. Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug’s binding affinity to D2 receptors, and carries lesser activity at several off-targets which may responsible for some of its undesirable effects. It is grouped under the following drug class(es): Mood stabilizers, Psychotropic agents and QTc-prolonging agents. Its therapeutic use is listed as antipsychotics, central nervous system (CNS) agents and mood stabilizers. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Risperin, Rispolin, Sequinan, Perseris, Psychodal and Zophrenal. Its PubChem CID is 5073.