Ridaforolimus

Ridaforolimus is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway. It is grouped under the following drug class(es): Kinase inhibitors. The directory classifies it as a discontinued API with a semi-synthetic source/manufacturing origin. Other names for this substance include Deforolimus, ridaforolimusum and Taltorvic. Its PubChem CID is 11520894.