(R)-1-(6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl)ethan-1-amine

It serves as the amine component in a nucleophilic aromatic substitution or coupling reaction, forming the core structure of the drug. It is often produced via chiral synthesis or resolution, such as using transaminase enzymes to ensure the specific S-configuration. (S)-1-(6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl)ethan-1-amine is a critical chiral intermediate in the synthesis of Pralsetinib.