Pibrozelesin is a semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis. The directory classifies it as a unknown/inactive API with a synthetic source/manufacturing origin. Other names for this substance include Pibrozelesinum and Pibrozelesina. Its PubChem CID is 132979.
Pibrozelesin
| CAS No | 154889-68-6 |
|---|---|
| Molecular Formula | C32H36BrN5O8 |
| Molecular Weight | 698.6 g/mol |
| Synonyms | methyl (8S)-8-(bromomethyl)-2-methyl-4-(4-methylpiperazine-1-carbonyl)oxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1-carboxylate |
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Pibrozelesin is a semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
The listed CAS number is 154889-68-6.
The listed molecular formula is C32H36BrN5O8.
The listed molecular weight is 698.6 g/mol.
methyl (8S)-8-(bromomethyl)-2-methyl-4-(4-methylpiperazine-1-carbonyl)oxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-7,8-dihydro-3H-pyrrolo[3,2-e]indole-1-carboxylate.
The source lists Pibrozelesinum and Pibrozelesina.