Aprotinin is a polypeptide protease inhibitor and a biologically derived active pharmaceutical ingredient (API). It consists of a single-chain basic polypeptide with 58 amino acids and functions as a broad-spectrum inhibitor of serine proteases, including trypsin, plasmin, and kallikrein. Aprotinin exerts its pharmacological effect by reversibly binding to proteolytic enzymes, thereby inhibiting fibrinolysis and reducing excessive protease activity. This mechanism results in reduced bleeding and blood loss, particularly during surgical procedures. The directory classifies it as a commercial API with a peptide source/manufacturing origin. Other names for this substance include Aprotinin and Bovine Aprotinin. Its PubChem CID is 16130295.
Pancreatic trypsin inhibitor
| CAS No | 9087-70-1 |
|---|---|
| Molecular Formula | C284H432N84O79S7 |
| Molecular Weight | 6511 g/mol |
| Synonyms | (3S)-4-[[(2S)-1-[[(1R,2aS,4S,5aS,8aS,11aS,13S,14aS,16S,17aR,19S,20aS,25S,26aS,29aS,31S,32aS,34S,35aS,37R,38aS,41aS,42R,44aS,45S,47aS,48S,50aS,51S,53aS,54R,56aS,57S,59aS,60S,62aS,63S,66S,69S,72S,75S,78S,81S,84S,87S,90S,93R)-29a,62a,69,84-tetrakis(4-aminobutyl)-35a,75,78-tris(2-amino-2-oxoethyl)-14a-(3-amino-3-oxopropyl)-8a,41a,72-tribenzyl-50a,53a-bis[(2S)-butan-2-yl]-47a,48,56a,81,90-pentakis(3-carbamimidamidopropyl)-31,60-bis(2-carboxyethyl)-42-[[2-[[2-[[(1S)-1-carboxyethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamoyl]-57-(carboxymethyl)-11a,13,45-tris[(1R)-1-hydroxyethyl]-66-(hydroxymethyl)-2a,16,38a,44a-tetrakis[(4-hydroxyphenyl)methyl]-26a,32a,59a,63,87-pentamethyl-20a,34-bis(2-methylpropyl)-51-(2-methylsulfanylethyl)-1a,3,4a,7a,9,10a,12,13a,15,16a,18,19a,22a,24,25a,28a,30,31a,33,34a,36,37a,40a,43a,44,46a,47,49a,50,52a,53,55a,56,58a,59,61a,62,64a,65,68,71,74,77,80,83,86,89,92,95,98-pentacontaoxo-5a-propan-2-yl-39,40,66a,67a,70a,71a-hexathia-a,2,3a,6a,8,9a,11,12a,14,15a,17,18a,21a,23,24a,27a,29,30a,32,33a,35,36a,39a,42a,43,45a,46,48a,49,51a,52,54a,55,57a,58,60a,61,63a,64,67,70,73,76,79,82,85,88,91,94,97-pentacontazahexacyclo[91.71.4.454,117.04,8.019,23.025,29]doheptacontahectan-37-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-1-[(2S)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoic acid |
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Frequently Asked Questions
Aprotinin is a polypeptide protease inhibitor and a biologically derived active pharmaceutical ingredient (API). It consists of a single-chain basic polypeptide with 58 amino acids and functions as a broad-spectrum inhibitor of serine proteases, including trypsin, plasmin, and kallikrein.
The listed CAS number is 9087-70-1.
The listed molecular formula is C284H432N84O79S7.
The listed molecular weight is 6511 g/mol.
The source lists Aprotinin and Bovine Aprotinin.
It is listed as a commercial API with a peptide origin.