Liposome-encapsulated OSI-7904 is a liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904. The directory classifies it as a discontinued API with a synthetic source/manufacturing origin. Other names for this substance include Gw-1843 and Liposome-encapsulated OSI-7904. Its PubChem CID is 135403832.
Osi-7904
| CAS No | 139987-54-5 |
|---|---|
| Molecular Formula | C27H24N4O6 |
| Molecular Weight | 500.5 g/mol |
| Synonyms | (2S)-2-[6-[(3-methyl-1-oxo-2H-benzo[f]quinazolin-9-yl)methylamino]-3-oxo-1H-isoindol-2-yl]pentanedioic acid |
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Liposome-encapsulated OSI-7904 is a liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication.
The listed CAS number is 139987-54-5.
The listed molecular formula is C27H24N4O6.
The listed molecular weight is 500.5 g/mol.
(2S)-2-[6-[(3-methyl-1-oxo-2H-benzo[f]quinazolin-9-yl)methylamino]-3-oxo-1H-isoindol-2-yl]pentanedioic acid.
The source lists Gw-1843 and Liposome-encapsulated OSI-7904.