Norbuprenorphine hydrochloride is the hydrochloride salt form of norbuprenorphine, that is a major active metabolite of the opioid modulator buprenorphine. Norbuprenorphine functions as a full agonist at μ-opioid, δ-opioid, and nociceptin receptors and as a partial agonist at κ-opioid receptors. It has potent respiratory depressant effects but relatively little pain-relieving (antinociceptive) effect compared to buprenorphine because it has limited ability to cross the blood-brain barrier, partly due to being a substrate of the P-glycoprotein efflux transporter. The directory classifies it as a unknown/inactive API with a semi-synthetic source/manufacturing origin. Other names for this substance include 6, 14-Ethenomorphinan-7-methanol, alpha-(1, 1-dimethylethyl)-4, 5-epoxy-18, 19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, hydrochloride, (alphaS, 5alpha and 7alpha)-. It is also listed for alternate use as: API Impurity. It is listed as a controlled drug substance (Schedule III). Its PubChem CID is 166177205.
Norbuprenorphine hydrochloride
| CAS No | 209963-02-0 |
|---|---|
| Molecular Formula | C25H36ClNO4 |
| Molecular Weight | 450.0 g/mol |
| Synonyms | (1S,2S,6R,14R,15R,16R)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol;hydrochloride |
Zoho Contact Form
"*" indicates required fields
Frequently Asked Questions
Norbuprenorphine hydrochloride is the hydrochloride salt form of norbuprenorphine, that is a major active metabolite of the opioid modulator buprenorphine. Norbuprenorphine functions as a full agonist at μ-opioid, δ-opioid, and nociceptin receptors and as a partial agonist at κ-opioid receptors.
The listed CAS number is 209963-02-0.
The listed molecular formula is C25H36ClNO4.
The listed molecular weight is 450.0 g/mol.
(1S,2S,6R,14R,15R,16R)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol;hydrochloride.
The source lists 6, 14-Ethenomorphinan-7-methanol, alpha-(1, 1-dimethylethyl)-4, 5-epoxy-18, 19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, hydrochloride, (alphaS, 5alpha and 7alpha)-.