Nalfurafine hydrochloride is an anti-itch (antipruritic) drug, approved in Japan, used for severe itching (pruritus) in patients with chronic kidney disease on hemodialysis or peritoneal dialysis, and those with chronic liver disease, especially when other treatments fail. It works as a selective kappa-opioid receptor agonist, reducing itch intensity, improving sleep, and enhancing quality of life, with a lower risk of addiction compared to traditional opioids. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Nopicor and Remitch. Its PubChem CID is 6918287.
Nalfurafine hydrochloride
| CAS No | 152658-17-8 |
|---|---|
| Molecular Formula | C28H33ClN2O5 |
| Molecular Weight | 513.0 g/mol |
| Synonyms | (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide;hydrochloride |
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Frequently Asked Questions
Nalfurafine hydrochloride is an anti-itch (antipruritic) drug, approved in Japan, used for severe itching (pruritus) in patients with chronic kidney disease on hemodialysis or peritoneal dialysis, and those with chronic liver disease, especially when other treatments fail.
The listed CAS number is 152658-17-8.
The listed molecular formula is C28H33ClN2O5.
The listed molecular weight is 513.0 g/mol.
(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide;hydrochloride.
The source lists Nopicor and Remitch.