Naldemedine tosylate is used to treat Opioid-Induced Constipation (OIC) in adults, particularly for those with chronic non-cancer pain or cancer-related pain, acting as a peripherally-acting mu-opioid receptor antagonist (PAMORA) that blocks opioid effects in the gut without reducing pain relief in the brain. It works by blocking opioid receptors in the intestines, preventing constipation caused by opioid pain medications, and is taken once daily as a tablet. Its therapeutic use is listed as laxatives. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include Symproic and Naldemedine Tosilate. Its PubChem CID is 56837137.
Naldemedine tosylate
| CAS No | 1345728-04-2 |
|---|---|
| Molecular Formula | C39H42N4O9S |
| Molecular Weight | 742.8 g/mol |
| Synonyms | (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,7,9-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]-1,2,4,5,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-6-carboxamide;4-methylbenzenesulfonic acid |
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Frequently Asked Questions
Naldemedine tosylate is used to treat Opioid-Induced Constipation (OIC) in adults, particularly for those with chronic non-cancer pain or cancer-related pain, acting as a peripherally-acting mu-opioid receptor antagonist (PAMORA) that blocks opioid effects in the gut without reducing pain relief in the brain.
The listed CAS number is 1345728-04-2.
The listed molecular formula is C39H42N4O9S.
The listed molecular weight is 742.8 g/mol.
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,7,9-trihydroxy-N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl]-1,2,4,5,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-6-carboxamide;4-methylbenzenesulfonic acid.
The source lists Symproic and Naldemedine Tosilate.