It contains the substituted aniline core and the indole–pyrimidine pharmacophoric structure that are characteristic of the final molecule. In the manufacturing process, this nitro-containing intermediate typically undergoes reduction to the corresponding diamine, followed by further functional group transformations and acrylamide side-chain introduction to yield the active pharmaceutical ingredient (API). N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)-2-nitro-1,4-benzenediamine is a key advanced intermediate used in the multistep synthesis of Osimertinib.
N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)-2-nitro-1,4-benzenediamine
| API Name | Osimertinib |
|---|---|
| CAS No | 1421372-67-9 |
| Molecular Formula | C25H29N7O3 |
| Molecular Weight | 475.5 g/mol |
| Synonyms | 4-N-[2-(dimethylamino)ethyl]-2-methoxy-4-N-methyl-1-N-[4-(1-methylindol-3-yl)pyrimidin-2-yl]-5-nitrobenzene-1,4-diamine |
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Frequently Asked Questions
It contains the substituted aniline core and the indole–pyrimidine pharmacophoric structure that are characteristic of the final molecule. In the manufacturing process, this nitro-containing intermediate typically undergoes reduction to the corresponding diamine, followed by further functional group transformations and acrylamide side-chain introduction to yield the active pharmaceutical ingredient (API). N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)-2-nitro-1,4-benzenediamine is a key advanced intermediate used in the multistep synthesis of Osimertinib.
The CAS number of N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)-2-nitro-1,4-benzenediamine is 1421372-67-9.
The molecular formula of N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)-2-nitro-1,4-benzenediamine is C25H29N7O3.
The listed molecular weight of N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)-2-nitro-1,4-benzenediamine is 475.5 g/mol.
N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)-2-nitro-1,4-benzenediamine is listed as being used in connection with the following API: Osimertinib.
The listed synonym or IUPAC name for N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)-2-nitro-1,4-benzenediamine is 4-N-[2-(dimethylamino)ethyl]-2-methoxy-4-N-methyl-1-N-[4-(1-methylindol-3-yl)pyrimidin-2-yl]-5-nitrobenzene-1,4-diamine.