It incorporates the chiral 1,2-diol and benzodioxane moiety along with the pyrrolidinylmethyl substituent, which are critical for the molecule’s glucosylceramide synthase inhibitory activity. This intermediate undergoes final functionalization, including salt formation with tartrate, to yield the active Eliglustat tartrate. Its stereochemistry and functional groups are essential for binding specificity and pharmacological potency. N-((1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl)octanamide is a key advanced intermediate in the synthesis of Eliglustat tartrate.
N-((1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl)octanamide
| API Name | Eliglustat tartrate |
|---|---|
| CAS No | 491833-29-5 |
| Molecular Formula | C23H36N2O4 |
| Molecular Weight | 404.5 g/mol |
| Synonyms | N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide |
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