Methylprednisolone acetate

Methylprednisolone Acetate is the acetate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and antiinflammatory effects. Methylprednisolone acetate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production including IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved. It is grouped under the following drug class(es): Corticosteroids, Steroids and Systemic corticosteroids. Its therapeutic use is listed as antirheumatic agents, dermatologicals and osteoarthritis agents. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include M-Predrol, Depo-Medrate, Medrol acetate and Mepred. Its PubChem CID is 5877.