The chloro-butyl side chain undergoes nucleophilic substitution with a suitable piperidine derivative, forming the key carbon–nitrogen bond required for the antihistamine structure. Subsequent hydrolysis and functional group modifications convert the ester and ketone functionalities to produce the final active drug, Fexofenadine Hydrochloride. Methyl 4-(4-chloro-1-oxobutyl)-α,α-dimethylbenzeneacetate serves as an important aryl-ketone intermediate in the synthesis of Fexofenadine Hydrochloride.
Methyl 4-(4-chloro-1-oxobutyl)-alpha,alpha-dimethylbenzeneacetate
| API Name | Fexofenadine hydrochloride |
|---|---|
| CAS No | 154477-54-0 |
| Molecular Formula | C15H19ClO3 |
| Molecular Weight | 282.76 g/mol |
| Synonyms | methyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate |
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Frequently Asked Questions
The chloro-butyl side chain undergoes nucleophilic substitution with a suitable piperidine derivative, forming the key carbon–nitrogen bond required for the antihistamine structure. Subsequent hydrolysis and functional group modifications convert the ester and ketone functionalities to produce the final active drug, Fexofenadine Hydrochloride. Methyl 4-(4-chloro-1-oxobutyl)-α,α-dimethylbenzeneacetate serves as an important aryl-ketone intermediate in the synthesis of Fexofenadine Hydrochloride.
The CAS number of Methyl 4-(4-chloro-1-oxobutyl)-alpha,alpha-dimethylbenzeneacetate is 154477-54-0.
The molecular formula of Methyl 4-(4-chloro-1-oxobutyl)-alpha,alpha-dimethylbenzeneacetate is C15H19ClO3.
The listed molecular weight of Methyl 4-(4-chloro-1-oxobutyl)-alpha,alpha-dimethylbenzeneacetate is 282.76 g/mol.
Methyl 4-(4-chloro-1-oxobutyl)-alpha,alpha-dimethylbenzeneacetate is listed as being used in connection with the following API: Fexofenadine hydrochloride.
The listed synonym or IUPAC name for Methyl 4-(4-chloro-1-oxobutyl)-alpha,alpha-dimethylbenzeneacetate is methyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate.