Methyl (3R)-3-(((1,1-dimethylethyl)dimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate

It acts as a building block, featuring a protected alcohol and a phosphonium ylide (Wittig reagent) for carbon-carbon bond formation, making it vital for constructing key fragments of these cholesterol-lowering medications. This specific chemical, Methyl (3R)-3-(((1,1-dimethylethyl)dimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, is mainly used in organic synthesis as a crucial intermediate for creating complex molecules, notably in the production of HMG-CoA reductase inhibitors like certain statins (e.g., Rosuvastatin), helping form pyrimidine or pyrrole rings in those drug structures.

API Name Rosuvastatin calcium
CAS No 147118-35-2
Molecular Formula C31H39O4PSi
Molecular Weight 534.7 g/mol
Synonyms methyl (3R)-3-[tert-butyl(dimethyl)silyl]oxy-5-oxo-6-(triphenyl-λ5-phosphanylidene)hexanoate