Manidipine dihydrochloride is a dihydropyridine-type calcium channel blocker used mainly for the treatment of mild to moderate essential hypertension (high blood pressure). This medication acts by inhibiting voltage-dependent calcium currents in vascular smooth muscle cells, leading to systemic vasodilation and a sustained reduction in blood pressure. Its antihypertensive effect is maintained over 24 hours with once-daily dosing, and clinical trials indicate efficacy comparable to other calcium channel blockers like amlodipine. Manidipine shows vascular selectivity, especially benefitting renal circulation, with studies noting a protective effect against kidney damage in hypertensive populations. It is grouped under the following drug class(es): Vasodilating agents. Its therapeutic use is listed as cardiovascular. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Manidipine HCl and Calslot. Its PubChem CID is 150762.
Manidipine dihydrochloride
| CAS No | 89226-75-5 |
|---|---|
| Molecular Formula | C35H40Cl2N4O6 |
| Molecular Weight | 683.60 g/mol |
| Synonyms | 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;dihydrochloride |
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Frequently Asked Questions
Manidipine dihydrochloride is a dihydropyridine-type calcium channel blocker used mainly for the treatment of mild to moderate essential hypertension (high blood pressure).
The listed CAS number is 89226-75-5.
The listed molecular formula is C35H40Cl2N4O6.
The listed molecular weight is 683.60 g/mol.
5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;dihydrochloride.
The source lists Manidipine HCl and Calslot.