Mafenide Hydrochloride

Mafenide Hydrochloride is a synthetic sulfonamide-derived antibacterial agent used mainly in the prevention and treatment of infections in severe burn wounds. It exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa, a common pathogen in burn-related infections. The drug acts by inhibiting bacterial folic acid synthesis, thereby preventing bacterial growth. Due to its ability to penetrate burn eschar effectively, it is particularly valuable in managing deep or extensive burns where other topical antibiotics may be less effective. The directory classifies it as a unknown/inactive API with a synthetic source/manufacturing origin. Other names for this substance include 4-Aminomethylbenzenesulfonamide hydrochloride and Homosulfamine hydrochloride. Its PubChem CID is 67313.