Losartan Potassium is the potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and functions as a vasoconstrictor in vascular smooth muscle. It is grouped under the following drug class(es): Angiotensin II Receptor Blockers (ARBs). Its therapeutic use is listed as antihypertensives and cardiovascular. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Cozaar, Losacar, Losaprex, Losata and Tancin. Its PubChem CID is 11751549.
Losartan potassium
| CAS No | 124750-99-8 |
|---|---|
| Molecular Formula | C22H22ClKN6O |
| Molecular Weight | 461.00 g/mol |
| Synonyms | potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol |
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Frequently Asked Questions
Losartan Potassium is the potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity.
The listed CAS number is 124750-99-8.
The listed molecular formula is C22H22ClKN6O.
The listed molecular weight is 461.00 g/mol.
potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol.
The source lists Cozaar, Losacar, Losaprex, Losata and Tancin.