Licofelone is a dual COX/LOX inhibitor drug studied for osteoarthritis, acting as an anti-inflammatory and analgesic by blocking both cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways, potentially reducing the GI side effects of traditional NSAIDs while also showing promise in neurological disorders due to its anti-inflammatory and neuroprotective effects. It aims to relieve pain and inflammation in conditions like arthritis, with studies exploring its use in spinal cord injury, epilepsy, and neuropathic pain. It is grouped under the following drug class(es): Cyclooxygenase‑2 (COX‑2) Inhibitors and Non-Steroidal Anti-Inflammatory Drugs (NSAID). Its therapeutic use is listed as anti-inflammatories. The directory classifies it as a discontinued API with a synthetic source/manufacturing origin. Other names for this substance include Licofelona and Licofelonum. Its PubChem CID is 133021.
Licofelone
| CAS No | 156897-06-2 |
|---|---|
| Molecular Formula | C23H22ClNO2 |
| Molecular Weight | 379.90 g/mol |
| Synonyms | 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid |
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Licofelone is a dual COX/LOX inhibitor drug studied for osteoarthritis, acting as an anti-inflammatory and analgesic by blocking both cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways, potentially reducing the GI side effects of traditional NSAIDs while also showing promise in neurological disorders due to its anti-inflammatory and neuroprotective effects.
The listed CAS number is 156897-06-2.
The listed molecular formula is C23H22ClNO2.
The listed molecular weight is 379.90 g/mol.
2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid.
The source lists Licofelona and Licofelonum.