Levamlodipine (S‑amlodipine) is the pharmacologically active enantiomer of amlodipine, used as a dihydropyridine calcium channel blocker for hypertension and related cardiovascular indications. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlodipine and levamlodipine may be used interchangeably as both substances are the same, however. As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity. Levamlodipine was granted FDA approval on 19 December 2019. It is grouped under the following drug class(es): Calcium Channel Blockers and Vasodilating agents. Its therapeutic use is listed as antihypertensives. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include S-Amlodipine and (-)-Amlodipine. Its PubChem CID is 9822750.
Levamlodipine
| CAS No | 103129-82-4 |
|---|---|
| Molecular Formula | C20H25ClN2O5 |
| Molecular Weight | 408.9 g/mol |
| Synonyms | 3-O-ethyl 5-O-methyl (4S)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
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Frequently Asked Questions
Levamlodipine (S‑amlodipine) is the pharmacologically active enantiomer of amlodipine, used as a dihydropyridine calcium channel blocker for hypertension and related cardiovascular indications.
The listed CAS number is 103129-82-4.
The listed molecular formula is C20H25ClN2O5.
The listed molecular weight is 408.9 g/mol.
3-O-ethyl 5-O-methyl (4S)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate.
The source lists S-Amlodipine and (-)-Amlodipine.