Leucovorin Calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, ‘rescuing’ the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug’s metabolite to its target enzyme, thus prolonging drug activity. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Rescuvolin, Calcii folinas, Folidan and Foliben. Its PubChem CID is 135403647.
Leucovorin calcium
| CAS No | 1492-18-8 |
|---|---|
| Molecular Formula | C20H21CaN7O7 |
| Molecular Weight | 511.50 g/mol |
| Synonyms | calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate |
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Frequently Asked Questions
Leucovorin Calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs.
The listed CAS number is 1492-18-8.
The listed molecular formula is C20H21CaN7O7.
The listed molecular weight is 511.50 g/mol.
calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate.
The source lists Rescuvolin, Calcii folinas, Folidan and Foliben.