Icatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B2 receptors with a similar affinity to bradykinin. It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than earlier B2 receptors antagonists, thus representing a new class of medication. It is grouped under the following drug class(es): Bradykinin B2 receptor antagonists and Peptides. The directory classifies it as a commercial API with a peptide source/manufacturing origin. Other names for this substance include icatibanto, Firazyr and icatibantum. Its PubChem CID is 6918173.
Icatibant
| CAS No | 130308-48-4 |
|---|---|
| Molecular Formula | C59H89N19O13S |
| Molecular Weight | 1304.5 g/mol |
| Synonyms | (2S)-2-[[(2S,3aS,7aS)-1-[(3R)-2-[(2S)-2-[[(2S)-2-[[2-[[(2S,4R)-1-[(2S)-1-[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
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Frequently Asked Questions
Icatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B2 receptors with a similar affinity to bradykinin.
The listed CAS number is 130308-48-4.
The listed molecular formula is C59H89N19O13S.
The listed molecular weight is 1304.5 g/mol.
The source lists icatibanto, Firazyr and icatibantum.
It is listed under Bradykinin B2 receptor antagonists and Peptides.