Hydrocortisone sodium succinate

Hydrocortisone Sodium Succinate is the sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, including various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation. It is grouped under the following drug class(es): Corticosteroids, Steroids and Systemic corticosteroids. Its therapeutic use is listed as anti-psoriatic agents, dermatologicals and osteoarthritis agents. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include Solu-Cortef and Nositrol. Its PubChem CID is 23694214.

CAS No 0125-04-02
Molecular Formula C25H33NaO8
Molecular Weight 484.5 g/mol
Synonyms sodium;4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate

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