Hydrocortisone Hemisuccinate is the synthetic hemisuccinate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, including cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes. It is grouped under the following drug class(es): Steroids. Its therapeutic use is listed as anti-psoriatic agents and dermatologicals. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include Hydrocortisone 21-hemisuccinate, Hydrocortisone hemisuccinate anhydrous and Hydrocortisone Hydrogen Succinate. Its PubChem CID is 219121.
Hydrocortisone hemisuccinate
| CAS No | 83784-20-7 |
|---|---|
| Molecular Formula | C25H36O9 |
| Molecular Weight | 480.5 g/mol |
| Synonyms | 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid;hydrate |
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Frequently Asked Questions
Hydrocortisone Hemisuccinate is the synthetic hemisuccinate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
The listed CAS number is 83784-20-7.
The listed molecular formula is C25H36O9.
The listed molecular weight is 480.5 g/mol.
4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid;hydrate.
The source lists Hydrocortisone 21-hemisuccinate, Hydrocortisone hemisuccinate anhydrous and Hydrocortisone Hydrogen Succinate.