Hydrocortisone butyrate

Hydrocortisone Butyrate is the butyrate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes, from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leading to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, that is essential for prostaglandin production. It is grouped under the following drug class(es): Corticosteroids and Steroids. Its therapeutic use is listed as anti-inflammatories, anti-psoriatic agents and central nervous system (CNS) agents. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include Locoid, Laticort, Hydrocortisone-17alpha-butyrate and Hycortate. Its PubChem CID is 26133.