Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. Its therapeutic use is listed as antiparasitics. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include Tempostatin and Stenorol. Its PubChem CID is 11591339.
Halofuginone hydrobromide
| CAS No | 64924-67-0 |
|---|---|
| Molecular Formula | C16H18Br2ClN3O3 |
| Molecular Weight | 495.6 g/mol |
| Synonyms | 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;hydrobromide |
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Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities.
The listed CAS number is 64924-67-0.
The listed molecular formula is C16H18Br2ClN3O3.
The listed molecular weight is 495.6 g/mol.
7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;hydrobromide.
The source lists Tempostatin and Stenorol.