Halobetasol propionate

Halobetasol Propionate is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, including prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability. It is grouped under the following drug class(es): Corticosteroids and Steroids. Its therapeutic use is listed as anti-psoriatic agents and dermatologicals. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include Ulobetasol propionate and Ultravate. Its PubChem CID is 6918178.