Fluorothymidine F-18 is a radioconjugate consisting of a thymidine analogue radiolabeled with fluorine F 18, a positron emitting isotope. Phosphorylated by S-phase-specific thymidine kinase 1, 3′-deoxy-3′-[18F]fluorothymidine (18F-FLT) is trapped intracellularly by entering the salvage pathway of DNA synthesis without incorporation into DNA. 18F-FLT serves a marker of tumor cell proliferation for imaging with positron emission tomography (PET); as a marker of proliferation rather than metabolism, it is more specific to tumor tissue than 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG). This agent is metabolically stable, accumulates in the normal bone marrow and the liver, and does not cross the blood-brain barrier. Its therapeutic use is listed as diagnostic agents. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include 18F-FLT, alovudine f-18 and 3′-deoxy-3′-(18F)fluorothymidine. Its PubChem CID is 9878109.
Fluorothymidine F-18
| CAS No | 287114-80-1 |
|---|---|
| Molecular Formula | C10H13FN2O4 |
| Molecular Weight | 243.22 g/mol |
| Synonyms | 1-[(2R,4S,5R)-4-(18F)fluoranyl-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
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Frequently Asked Questions
Fluorothymidine F-18 is a radioconjugate consisting of a thymidine analogue radiolabeled with fluorine F 18, a positron emitting isotope.
The listed CAS number is 287114-80-1.
The listed molecular formula is C10H13FN2O4.
The listed molecular weight is 243.22 g/mol.
1-[(2R,4S,5R)-4-(18F)fluoranyl-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione.
The source lists 18F-FLT, alovudine f-18 and 3'-deoxy-3'-(18F)fluorothymidine.