Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. The directory classifies it as a clinical API with a synthetic source/manufacturing origin. Other names for this substance include Exatecan mesylate and Exatecan mesylate dihydrate. Its PubChem CID is 151114.
DX-8951F
| CAS No | 197720-53-9 |
|---|---|
| Molecular Formula | C25H30FN3O9S |
| Molecular Weight | 567.6 g/mol |
| Synonyms | (10S,23S)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione;methanesulfonic acid;dihydrate |
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Frequently Asked Questions
Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity.
The listed CAS number is 197720-53-9.
The listed molecular formula is C25H30FN3O9S.
The listed molecular weight is 567.6 g/mol.
(10S,23S)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione;methanesulfonic acid;dihydrate.
The source lists Exatecan mesylate and Exatecan mesylate dihydrate.