Difenoxin

Difenoxin is a piperidinemonocarboxylic acid that is 4-phenylpiperidine-4-carboxylic acid in which the hydrogen attached to the nitrogen atom is substituted by a 3-cyano-3,3-diphenylpropyl group. Among its listed roles, it functions as a antidiarrhoeal drug. It is a nitrile, a piperidinemonocarboxylic acid and a tertiary amine. Difenoxin is a DEA Schedule I controlled substance. Substances in the DEA Schedule I have no currently accepted medical use in the United States, a lack of accepted safety for use under medical supervision, and a high potential for abuse. It is a Opiates substance. Difenoxin is an Antidiarrheal. Difenoxin is a phenylpiperidine with antidiarrheal activity and an active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid meperidine. Difenoxin acts mainly on the gastrointestinal wall by binding to opioid receptors on acetylcholine-containing nerves and inhibiting the release of acetylcholine from presynaptic nerve terminals. This leads to a reduction in intestinal motility. Difenoxin hydrochloride also mimics the action of endogenous opioid peptides at the CNS opioid receptors, (mainly mu-receptors), thereby inducing CNS effects. Its therapeutic use is listed as antidiarrheals. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Diphenoxylic acid, Difenoxine, Difenoxina and Difenoxinum. Its PubChem CID is 34328.