Cortisone

Cortisone is a C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20. Among its listed roles, it functions as a mouse metabolite and a human metabolite. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a glucocorticoid, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, a 20-oxo steroid, an 11-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid. It is derived from a hydride of a pregnane. A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite hydrocortisone. It is grouped under the following drug class(es): Corticosteroids and Systemic corticosteroids. Its therapeutic use is listed as anti-inflammatories. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include Kendall’s compound E, Reichstein’s substance FA and Wintersteiner’s compound F. Its PubChem CID is 222786.