Clobetasol

Clobetasol is a 3-oxo-1,4-steroid that is 16beta-methylpregna-1,4-diene-3,20-dione bearing hydroxy groups at the 11beta and 17alpha positions, fluorine at position 9, and a chlorine substituent at position 21. It is used as its 17alpha-propionate ester to treat various skin disorders, including exzema and psoriasis. Among its listed roles, it functions as a SMO receptor agonist and an anti-inflammatory drug. It is a tertiary alpha-hydroxy ketone, a glucocorticoid, a 17alpha-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a chlorinated steroid. It is grouped under the following drug class(es): Corticosteroids. Its therapeutic use is listed as anti-inflammatories. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Clobetasolum and Clobecort Amex. Its PubChem CID is 5311051.

CAS No 25122-41-2
Molecular Formula C22H28ClFO4
Molecular Weight 410.9 g/mol
Synonyms (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

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