Chloromethyl isopropyl carbonate

It’s a versatile reagent for making other fine chemicals, but its presence as a potential mutagenic impurity in Tenofovir formulations has raised significant health concerns and regulatory scrutiny from bodies like the World Health Organization (WHO). Chloromethyl isopropyl carbonate (CMIC) is a key organic intermediate mainly used in the pharmaceutical industry to synthesize antiviral drugs like Tenofovir, which treats HIV and Hepatitis B, acting as a building block in its complex chemical production.

API Name Tenofovir disoproxil fumarate
CAS No 35180-01-9
Molecular Formula C5H9ClO3
Molecular Weight 152.57 g/mol
Synonyms chloromethyl propan-2-yl carbonate