CB-5083 is an orally bioavailable inhibitor of valosin-containing protein (VCP) p97, with potential antineoplastic activity. Upon oral administration, CB-5083 specifically binds to and inhibits the activity of p97. This prevents ubiquitin-dependent protein degradation and causes cellular accumulation of poly-ubiquitinated proteins. The directory classifies it as a discontinued API with a synthetic source/manufacturing origin. Other names for this substance include p97 Inhibitor CB-5083 and JDP. Its PubChem CID is 73051434.
Cb-5083
| CAS No | 1542705-92-9 |
|---|---|
| Molecular Formula | C24H23N5O2 |
| Molecular Weight | 413.5 g/mol |
| Synonyms | 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide |
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CB-5083 is an orally bioavailable inhibitor of valosin-containing protein (VCP) p97, with potential antineoplastic activity. Upon oral administration, CB-5083 specifically binds to and inhibits the activity of p97.
The listed CAS number is 1542705-92-9.
The listed molecular formula is C24H23N5O2.
The listed molecular weight is 413.5 g/mol.
1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide.
The source lists p97 Inhibitor CB-5083 and JDP.