Calcipotriol is a seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients. Among its listed roles, it functions as a drug allergen and an antipsoriatic. It belongs to the class of cyclopropanes, a secondary alcohol, a triol, a hydroxy seco-steroid and a seco-cholestane. Its therapeutic use is listed as anti-psoriatic agents and dermatologicals. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include Dovonex, Daivonex and calcipotriene. Its PubChem CID is 5288783.
Calcipotriol
| CAS No | 112965-21-6 |
|---|---|
| Molecular Formula | C27H40O3 |
| Molecular Weight | 412.6 g/mol |
| Synonyms | trans-(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol |
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Frequently Asked Questions
Calcipotriol is a seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.
The listed CAS number is 112965-21-6.
The listed molecular formula is C27H40O3.
The listed molecular weight is 412.6 g/mol.
trans-(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol.
The source lists Dovonex, Daivonex and calcipotriene.